用于群体 PK/PD 的元分析框架——可将模型拟合到汇总层级数据(每项研究的均值和协方差)或已发布的 PK/PD 模型,属于 nlmixr2 / rxode2 生态系统。
AI 翻译
A meta-analysis framework for population PK/PD — fit models to summary-level data (means and covariances per study) or to previously published PK/PD models, in the nlmixr2 / rxode2 ecosystem.
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admixr2 is a meta-analysis framework for population PK/PD. It fits
pharmacometric models directly to summary-level data — the mean vector E
and covariance matrix V reported per study — instead of individual patient
records. The inputs can be digitised aggregate data from published studies,
previously published PK/PD models, or a mix of both; the result is a single
unified population model with interpretable fixed, random and covariate effects.
It integrates with the nlmixr2 /
rxode2 ecosystem and provides four
estimation backends:查看完整 README ↗目前无法加载完整 README。请通过原文链接阅读。 以下为已保存的摘录。
admixr2 is a meta-analysis framework for population PK/PD. It fits
pharmacometric models directly to summary-level data — the mean vector E
and covariance matrix V reported per study — instead of individual patient
records. The inputs can be digitised aggregate data from published studies,
previously published PK/PD models, or a mix of both; the result is a single
unified population model with interpretable fixed, random and covariate effects.
It integrates with the nlmixr2 /
rxode2 ecosystem and provides four
estimation backends:查看完整 README ↗