Drosophila Synaptic Cafe — Biological Connectome Neural Simulation

Interactive computational neuroscience sandbox featuring an authentic Drosophila melanogaster (fruit fly) synaptic connectome network, Leaky Integrate-and-Fire (LIF) neural simulation, real-time auditory sonification, and 3D visualizer.

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🚀 Live Interactive Simulation

Step into the Drosophila Synaptic Cafe and observe connectome neural firing in real time:
👉 Launch Drosophila Neural Simulation

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✨ Scientific & Engineering Features

• Authentic Connectome Architecture: Models realistic synaptic connectivity matrices derived from full adult fruit fly brain datasets (130,000+ neurons and 50M+ synaptic connections).
• Leaky Integrate-and-Fire (LIF) Dynamics: Simulates membrane potential decay, synaptic current integration, absolute refractory periods, and threshold spike propagation.
• Auditory Sonification (NeuroAudio.js): Real-time auditory synthesis translating neural spike trains and oscillatory rhythms into musical harmony.
• Hardware-Accelerated WebGL Visualizer: 3D spatial neuron mapping with dynamic synaptic fire illumination and telemetry oscilloscopes.

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🛠️ Simulation Pipeline

┌─────────────────────────┐       ┌────────────────────────┐       ┌──────────────────────┐
│  Biological Connectome  │ ───>  │ Leaky Integrate-&-Fire │ ───>  │  Motor Actions &     │
│  Synaptic Weight Matrix │       │  Spike Engine (Worker) │       │  Sensory Feedback    │
└─────────────────────────┘       └────────────────────────┘       └──────────┬───────────┘
                                                                              │
                                                   ┌──────────────────────────┴──────────────────────────┐
                                                   ▼                                                     ▼
                                       ┌─────────────────────────┐                           ┌───────────────────────┐
                                       │   Real-Time Sonification│                           │  WebGL 3D Connectome  │
                                       │   WebAudio Synthesizer  │                           │  Neural Oscilloscope  │
                                       └─────────────────────────┘                           └───────────────────────┘

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📦 Project Architecture

• Connectome.js: Core neural graph adjacency list and synaptic connection topology.
• FlyNeuralEngine.js: LIF membrane potential solver and neural plasticity coordinator.
• FullBrainWorker.js: Offscreen multithreaded Web Worker executing continuous neural step integration at 60 FPS.
• ConnectomeVisualizer.js: 3D WebGL renderer displaying real-time synaptic pulse propagations.
• NeuroAudio.js: Low-latency WebAudio engine translating spike train frequencies into musical acoustics.

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📄 License

Distributed under the MIT License. See LICENSE for more information.